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Academic and industrial efforts have progressively advanced from single-tissue to multi-tissue and multi-organ OoC systems, converging toward autologous OoC (aOoC) platforms that can (i) capture patient-specific immunopathophysiology with higher fidelity, (ii) potentially complement and, in specific contexts, reduce reliance on animal models, and (iii) directly inform immunotherapy development and therapeutic decision-making within precision medicine

When a free radical encounters a skin cell, it damages the cell membrane, the collagen fibers that keep skin firm, and sometimes even the DNA inside the cell

This is due to the cumulative effect of reducing oxidative stress and inhibiting melanin synthesis

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